| NAME | TEAM | ATT | YDS | AVG | TD |
| S.Alexander | WSH | 370 | 1880 | 5.1 | 27 |
| T.Barber | NYG | 357 | 1860 | 5.2 | 9 |
| C.Portis | WSH | 352 | 1516 | 4.3 | 11 |
| W.Dunn | TB | 280 | 1416 | 5.1 | 3 |
| T.Jones | KC | 314 | 1335 | 4.3 | 9 |
| C.Williams | STL | 290 | 1178 | 4.1 | 6 |
| S.Jackson | ATL | 254 | 1046 | 4.1 | 8 |
| J.Jones | NO | 257 | 993 | 3.9 | 5 |
| D.Foster | SF | 205 | 879 | 4.3 | 2 |
| K.Jones | CHI | 186 | 664 | 3.6 | 5 |
| M.Moore | IND | 155 | 662 | 4.3 | 1 |
| A.Smith | HOU | 166 | 659 | 4.0 | 3 |
| B.Westbrook | SF | 156 | 617 | 4.0 | 3 |
| F.Gore | SF | 127 | 608 | 4.8 | 3 |
| M.Vick | PHI | 102 | 597 | 5.9 | 6 |
| S.Gado | TEN | 143 | 582 | 4.1 | 6 |
| K.Barlow | PIT | 176 | 581 | 3.3 | 3 |
| S.Davis | STL | 180 | 549 | 3.1 | 12 |
| M.Barber | CHI | 138 | 538 | 3.9 | 5 |
| M.Bennett | OAK | 126 | 473 | 3.8 | 3 |